| Tissue Specificity | |
| Post Translational Modifications | |
| Function | Component of N-methyl-D-aspartate (NMDA) receptors (NMDARs) that function as heterotetrameric, ligand-gated cation channels with high calcium permeability and voltage-dependent block by Mg(2+). Participates in synaptic plasticity for learning and memory formation. Channel activation requires binding of the neurotransmitter L-glutamate to the GluN2 subunit, glycine or D-serine binding to the GluN1 subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+). NMDARs mediate simultaneously the potasium efflux and the influx of calcium and sodium. Each GluN2 subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, Ca2(+) permeability, and binding to allosteric modulators. |
| Protein Name | Glutamate Receptor Ionotropic - Nmda 2dGlun2dEb11Glutamate Nmda Receptor Subunit Epsilon-4N-Methyl D-Aspartate Receptor Subtype 2dNmdar2dNr2d |
| Database Links | Reactome: R-HSA-438066Reactome: R-HSA-442982Reactome: R-HSA-5673001Reactome: R-HSA-6794361Reactome: R-HSA-8849932Reactome: R-HSA-9609736Reactome: R-HSA-9617324Reactome: R-HSA-9620244 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinPostsynaptic Cell Membrane |
| Alternative ELISA Names | Glutamate Receptor Ionotropic - Nmda 2d ELISA kitGlun2d ELISA kitEb11 ELISA kitGlutamate Nmda Receptor Subunit Epsilon-4 ELISA kitN-Methyl D-Aspartate Receptor Subtype 2d ELISA kitNmdar2d ELISA kitNr2d ELISA kitGRIN2D ELISA kitGluN2D ELISA kitNMDAR2D ELISA kit |
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Information sourced from Uniprot.org
