Human GRB14 protein (Recombinant) (N-His) (STJP015909)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human GRB14-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin | Please contact us for further information. |
Target Information
| Gene Symbol | GRB14 |
| Gene ID | 2888 |
| Uniprot ID | GRB14_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Arg105-Leu540 |
Additional Info
| Post Translational Modifications | Phosphorylated on serine residues. Phosphorylated on tyrosine residues by TEK/TIE2. |
| Function | Adapter protein which modulates coupling of cell surface receptor kinases with specific signaling pathways. Binds to, and suppresses signals from, the activated insulin receptor (INSR). Potent inhibitor of insulin-stimulated MAPK3 phosphorylation. Plays a critical role regulating PDPK1 membrane translocation in response to insulin stimulation and serves as an adapter protein to recruit PDPK1 to activated insulin receptor, thus promoting PKB/AKT1 phosphorylation and transduction of the insulin signal. |
| Protein Name | Growth Factor Receptor-Bound Protein 14Grb14 Adapter Protein |
| Database Links | Reactome: R-HSA-210993 |
| Cellular Localisation | CytoplasmEndosome MembranePeripheral Membrane ProteinUpon Insulin StimulationTranslocates To The Plasma Membrane |
| Alternative Protein Names | Growth Factor Receptor-Bound Protein 14 proteinGrb14 Adapter Protein proteinGRB14 protein |
Information sourced from Uniprot.org