Human GRB14 protein (Recombinant) (N-His) (STJP015909)

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STJP015909
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Short Description :Recombinant-Human GRB14-N-His protein was developed from e.coli for the region N-His. For use in research applications.
Applications:ELISA/Immunogen/SDS-PAGE/WB
Host:E.coli
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Dilution Range:Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Formulation:Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction:Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Endotoxin:Please contact us for further information.
Gene Symbol:GRB14
Gene ID:2888
Uniprot ID:GRB14_HUMAN
Immunogen:Homo sapiens (Human)
Immunogen Region:Arg105-Leu540
Post Translational Modifications Phosphorylated on serine residues. Phosphorylated on tyrosine residues by TEK/TIE2.
Function Adapter protein which modulates coupling of cell surface receptor kinases with specific signaling pathways. Binds to, and suppresses signals from, the activated insulin receptor (INSR). Potent inhibitor of insulin-stimulated MAPK3 phosphorylation. Plays a critical role regulating PDPK1 membrane translocation in response to insulin stimulation and serves as an adapter protein to recruit PDPK1 to activated insulin receptor, thus promoting PKB/AKT1 phosphorylation and transduction of the insulin signal.
Protein Name Growth Factor Receptor-Bound Protein 14
Grb14 Adapter Protein
Database Links Reactome: R-HSA-210993
Cellular Localisation Cytoplasm
Endosome Membrane
Peripheral Membrane Protein
Upon Insulin Stimulation
Translocates To The Plasma Membrane
Alternative Protein Names Growth Factor Receptor-Bound Protein 14 protein
Grb14 Adapter Protein protein
GRB14 protein

Information sourced from Uniprot.org

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