Human Granzyme H protein (Recombinant) (His-Tag) (STJP019125)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human Granzyme H-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE/Denatured |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 0.25 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 10% Glycerol |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | GZMH |
| Gene ID | 2999 |
| Uniprot ID | GRAH_HUMAN |
| Accession Number | NP_219491 |
| Immunogen | Human |
| Immunogen Region | 20-246aa |
| Immunogen Sequence | MGSSHHHHHH SSGLVPRGSH MEIIGGHEAK PHSRPYMAFV QFLQEKSRKR CGGILVRKDF VLTAAHCQGS SINVTLGAHN IKEQERTQQF IPVKRPIPHP AYNPKNFSND IMLLQLERKA KWTTAVRPLR LPSSKAQVKP GQLCSVAGWG YVSMSTLATT LQEVLLTVQK DCQCERLFHG NYSRATEICV GDPKKTQTGF KGDSGGPLVC KDVAQGILSY GNKKGTPP |
Additional Info
| Tissue Specificity | Constitutively expressed in NK cells. |
| Function | Cytotoxic chymotrypsin-like serine protease with preference for bulky and aromatic residues at the P1 position and acidic residues at the P3' and P4' sites. Probably necessary for target cell lysis in cell-mediated immune responses. Participates in the antiviral response via direct cleavage of several proteins essential for viral replication. |
| Protein Name | Granzyme HCcp-XCathepsin G-Like 2Ctsgl2Cytotoxic T-Lymphocyte ProteinaseCytotoxic Serine Protease CCsp-C |
| Database Links | Reactome: R-HSA-2022377Reactome: R-HSA-381426 |
| Cellular Localisation | Cytolytic Granule |
| Alternative Protein Names | Granzyme H proteinCcp-X proteinCathepsin G-Like 2 proteinCtsgl2 proteinCytotoxic T-Lymphocyte Proteinase proteinCytotoxic Serine Protease C proteinCsp-C proteinGZMH proteinCGL2 proteinCTSGL2 protein |
Information sourced from Uniprot.org