| Host: | HEK293 cells |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Conjugation: | Unconjugated |
| Formulation: | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Immunoreactivity: | Measured by its ability to cleave a peptide substrate, tButyloxycaronylAlaAlaAspThioBenzylester (BocAADSBzl) , in the presence of 5, 5 Dithiobis (2nitrobenzoic acid) (DTNB). The specific activity is >1500 pmol/min/Mu g. (The enzyme needs to be activa |
| Determination Method: | <1 EU/Mu g |
| Gene Symbol: | GZMB |
| Gene ID: | 3002 |
| Uniprot ID: | GRAB_HUMAN |
| Immunogen: | Recombinant Human Granzyme B Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Gly19-Tyr247) of human Granzyme B (Accession #NP_004122.1) fused with a 6×His tag at the C-terminus. |
| Immunogen Region: | Gly19-Tyr247 |
| Immunogen Sequence: | GEIIGGHEAKPHSRPYMAYL MIWDQKSLKRCGGFLIRDDF VLTAAHCWGSSINVTLGAHN IKEQEPTQQFIPVKRPIPHP AYNPKNFSNDIMLLQLERKA KRTRAVQPLRLPSNKAQVKP GQTCSVAGWGQTAPLGKHSH TLQEVKMTVQEDRKCESDLR HYYDSTIELCVGDPEIKKTS FKGDSGGPLVCNKVAQGIVS YGRNNGMPPRACTKVSSFVH WIKKTMKRY |
| Protein Name | Granzyme BC11Ctla-1Cathepsin G-Like 1Ctsgl1Cytotoxic T-Lymphocyte Proteinase 2Lymphocyte ProteaseFragmentin-2Granzyme-2Human Lymphocyte ProteinHlpSectT-Cell Serine Protease 1-3e |
| Database Links | Reactome: R-HSA-2197563Reactome: R-HSA-5620971Reactome: R-HSA-75108Reactome: R-HSA-9725371 |
| Cellular Localisation | SecretedCytolytic GranuleDelivered Into The Target Cell By Perforin |
| Alternative Protein Names | Granzyme B proteinC11 proteinCtla-1 proteinCathepsin G-Like 1 proteinCtsgl1 proteinCytotoxic T-Lymphocyte Proteinase 2 proteinLymphocyte Protease proteinFragmentin-2 proteinGranzyme-2 proteinHuman Lymphocyte Protein proteinHlp proteinSect proteinT-Cell Serine Protease 1-3e proteinGZMB proteinCGL1 proteinCSPB proteinCTLA1 proteinGRB protein |
Information sourced from Uniprot.org
