Human GPR137B protein (Recombinant) (N-GST & C-His) (STJP016359)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human GPR137B-N-GST & C-His protein was developed from e.coli for the region N-GST & C-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin | Please contact us for further information. |
Target Information
| Gene Symbol | GPR137B |
| Gene ID | 7107 |
| Uniprot ID | G137B_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Val315-Gly399 |
Additional Info
| Function | Lysosomal integral membrane protein that regulates the localization and activity of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Interacts with Rag GTPases and increases the lysosomial localization and activity of Rag GTPases and thereby regulates mTORC1 translocation and activity in lysosome. Involved in the regulation of lysosomal morphology and autophagy. Also acts as a negative regulator of osteoclast activity. Involved in interleukin-4-induced M2 macrophage polarization. |
| Protein Name | Integral Membrane Protein Gpr137bTransmembrane 7 Superfamily Member 1 Protein |
| Database Links | |
| Cellular Localisation | Lysosome MembraneMulti-Pass Membrane ProteinColocalized With Mtor In Lysosome After Amino Acid Stimulation |
| Alternative Protein Names | Integral Membrane Protein Gpr137b proteinTransmembrane 7 Superfamily Member 1 Protein proteinGPR137B proteinTM7SF1 protein |
Information sourced from Uniprot.org