| Function | Lysosomal integral membrane protein that regulates the localization and activity of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Interacts with Rag GTPases and increases the lysosomial localization and activity of Rag GTPases and thereby regulates mTORC1 translocation and activity in lysosome. Involved in the regulation of lysosomal morphology and autophagy. Also acts as a negative regulator of osteoclast activity. Involved in interleukin-4-induced M2 macrophage polarization. |
| Protein Name | Integral Membrane Protein Gpr137bTransmembrane 7 Superfamily Member 1 Protein |
| Database Links | |
| Cellular Localisation | Lysosome MembraneMulti-Pass Membrane ProteinColocalized With Mtor In Lysosome After Amino Acid Stimulation |
| Alternative Protein Names | Integral Membrane Protein Gpr137b proteinTransmembrane 7 Superfamily Member 1 Protein proteinGPR137B proteinTM7SF1 protein |
Information sourced from Uniprot.org