Human GPR137B protein (Recombinant) (N-GST & C-His) (STJP016359)

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STJP016359
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Short Description :Recombinant-Human GPR137B-N-GST & C-His protein was developed from e.coli for the region N-GST & C-His. For use in research applications.
Applications:ELISA/Immunogen/SDS-PAGE/WB
Host:E.coli
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Dilution Range:Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Formulation:Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction:Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Endotoxin:Please contact us for further information.
Gene Symbol:GPR137B
Gene ID:7107
Uniprot ID:G137B_HUMAN
Immunogen:Homo sapiens (Human)
Immunogen Region:Val315-Gly399
Function Lysosomal integral membrane protein that regulates the localization and activity of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Interacts with Rag GTPases and increases the lysosomial localization and activity of Rag GTPases and thereby regulates mTORC1 translocation and activity in lysosome. Involved in the regulation of lysosomal morphology and autophagy. Also acts as a negative regulator of osteoclast activity. Involved in interleukin-4-induced M2 macrophage polarization.
Protein Name Integral Membrane Protein Gpr137b
Transmembrane 7 Superfamily Member 1 Protein
Database Links
Cellular Localisation Lysosome Membrane
Multi-Pass Membrane Protein
Colocalized With Mtor In Lysosome After Amino Acid Stimulation
Alternative Protein Names Integral Membrane Protein Gpr137b protein
Transmembrane 7 Superfamily Member 1 Protein protein
GPR137B protein
TM7SF1 protein

Information sourced from Uniprot.org