| Function | In the cytoplasm, catalyzes the conversion of glucose-6-phosphate to fructose-6-phosphate, the second step in glycolysis, and the reverse reaction during gluconeogenesis. Besides it's role as a glycolytic enzyme, also acts as a secreted cytokine: acts as an angiogenic factor (AMF) that stimulates endothelial cell motility. Acts as a neurotrophic factor, neuroleukin, for spinal and sensory neurons. It is secreted by lectin-stimulated T-cells and induces immunoglobulin secretion. |
| Protein Name | Glucose-6-Phosphate IsomeraseGpiAutocrine Motility FactorAmfNeuroleukinNlkPhosphoglucose IsomerasePgiPhosphohexose IsomerasePhiSperm Antigen 36Sa-36 |
| Database Links | Reactome: R-HSA-5628897Reactome: R-HSA-6798695Reactome: R-HSA-70171Reactome: R-HSA-70263 |
| Cellular Localisation | CytoplasmSecreted |
| Alternative Protein Names | Glucose-6-Phosphate Isomerase proteinGpi proteinAutocrine Motility Factor proteinAmf proteinNeuroleukin proteinNlk proteinPhosphoglucose Isomerase proteinPgi proteinPhosphohexose Isomerase proteinPhi proteinSperm Antigen 36 proteinSa-36 proteinGPI protein |
Information sourced from Uniprot.org