Human GNPDA1 protein (Recombinant) (His-Tag) (STJP016841)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human GNPDA1-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 1 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 1mM DTT, 20% Glycerol, 50mM NaCl |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | GNPDA1 |
| Gene ID | 10007 |
| Uniprot ID | GNPI1_HUMAN |
| Accession Number | NP_005462 |
| Immunogen | Human |
| Immunogen Region | 1-289aa |
| Immunogen Sequence |
Additional Info
| Function | Catalyzes the reversible conversion of alpha-D-glucosamine 6-phosphate (GlcN-6P) into beta-D-fructose 6-phosphate (Fru-6P) and ammonium ion, a regulatory reaction step in de novo uridine diphosphate-N-acetyl-alpha-D-glucosamine (UDP-GlcNAc) biosynthesis via hexosamine pathway. Deamination is coupled to aldo-keto isomerization mediating the metabolic flux from UDP-GlcNAc toward Fru-6P. At high ammonium level can drive amination and isomerization of Fru-6P toward hexosamines and UDP-GlcNAc synthesis. Has a role in fine tuning the metabolic fluctuations of cytosolic UDP-GlcNAc and their effects on hyaluronan synthesis that occur during tissue remodeling. Seems to trigger calcium oscillations in mammalian eggs. These oscillations serve as the essential trigger for egg activation and early development of the embryo. |
| Protein Name | Glucosamine-6-Phosphate Deaminase 1Glcn6p Deaminase 1Glucosamine-6-Phosphate Isomerase 1Protein Oscillin |
| Database Links | Reactome: R-HSA-70171 |
| Cellular Localisation | Cytoplasm |
| Alternative Protein Names | Glucosamine-6-Phosphate Deaminase 1 proteinGlcn6p Deaminase 1 proteinGlucosamine-6-Phosphate Isomerase 1 proteinProtein Oscillin proteinGNPDA1 proteinGNPI proteinHLN proteinKIAA0060 protein |
Information sourced from Uniprot.org