| Short Description : | Recombinant-Active-Human GNLY/Granulysin-C-10*His protein was developed from mammalian cells and has a target region of C-10*His. For use in research applications. |
| Applications: | ELISA/WB |
| Host: | Mammalian Cells |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Conjugation: | Unconjugated |
| Dilution Range: | Reconstitute in sterile water for a stock solution. |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol. |
| Storage Instruction: | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin: | <0.1 EU/Mu g of the protein by the LAL method. |
| Immunoreactivity: | Measured by its ability to induce RANTES secretion by human acute monocytic leukemia cells (THP‑1). The ED50 for this effect is 0.3-1 µg/mL, in the presence of 10 µg/mL of a crosslinking antibody Mouse Anti-His Antibody. |
| Gene Symbol: | GNLY |
| Gene ID: | 10578 |
| Uniprot ID: | GNLY_HUMAN |
| Immunogen: | Homo sapiens (Human) |
| Immunogen Region: | Met1-Leu145 |
| Post Translational Modifications | A 9 kDa form is produced by proteolytic processing of a 15 kDa protein. |
| Function | Antimicrobial protein that kills intracellular pathogens. Active against a broad range of microbes, including Gram-positive and Gram-negative bacteria, fungi, and parasites. Kills Mycobacterium tuberculosis. |
| Protein Name | GranulysinLymphokine Lag-2Protein Nkg5T-Cell Activation Protein 519 |
| Database Links | Reactome: R-HSA-6803157 |
| Cellular Localisation | SecretedLocated In The Cytotoxic Granules Of T-CellsWhich Are Released Upon Antigen Stimulation |
| Alternative Protein Names | Granulysin proteinLymphokine Lag-2 proteinProtein Nkg5 proteinT-Cell Activation Protein 519 proteinGNLY proteinLAG2 proteinNKG5 proteinTLA519 protein |
Information sourced from Uniprot.org