Human GNAI2 (Guanine Nucleotide-Binding Protein G (i) Subunit Alpha-2) Sandwich ELISA Kit Ready-To-Use Kit (STJE0015603)

Human GNAI2 (Guanine Nucleotide-Binding Protein G (i) Subunit Alpha-2) Sandwich ELISA Kit Ready-To-Use Kit (STJE0015603)

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STJE0015603
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Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.132ng/mL
Detection Limit: 0.312-20ng/mL
Short Description : This GNAI2 Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human serum, plasma, tissue homogenates or other biological fluids..
Storage Instruction: The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 3 hrs
Gene Symbol: GNAI2
Gene ID: 2771
Uniprot ID: GNAI2_HUMAN
Immunogen Region: Ready-To-Use
Sample Type: serum, plasma, tissue homogenates or other biological fluids.
Tissue Specificity
Post Translational Modifications (Microbial infection) Deamidated at Gln-205 by Photorhabdus asymbiotica toxin PAU_02230, blocking GTP hydrolysis of heterotrimeric GNAQ or GNA11 and G-alphai (GNAI1, GNAI2 or GNAI3) proteins, thereby activating RhoA.
Function Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. May play a role in cell division. Isoform sGi2: Regulates the cell surface density of dopamine receptors DRD2 by sequestrating them as an intracellular pool.
Protein Name Guanine Nucleotide-Binding Protein G(I Subunit Alpha-2
Adenylate Cyclase-Inhibiting G Alpha Protein
Database Links Reactome: R-HSA-170670
Reactome: R-HSA-392170
Reactome: R-HSA-400042
Reactome: R-HSA-418555
Reactome: R-HSA-418594
Reactome: R-HSA-418597
Reactome: R-HSA-422356
Reactome: R-HSA-9009391
Reactome: R-HSA-9634597
Reactome: R-HSA-9660821
Cellular Localisation Cytoplasm
Cytoskeleton
Microtubule Organizing Center
Centrosome
Cell Membrane
Membrane
Lipid-Anchor
Localizes In The Centrosomes Of Interphase And Mitotic Cells
Detected At The Cleavage Furrow And/Or The Midbody
Alternative ELISA Names Guanine Nucleotide-Binding Protein G(I Subunit Alpha-2 ELISA kit
Adenylate Cyclase-Inhibiting G Alpha Protein ELISA kit
GNAI2 ELISA kit
GNAI2B ELISA kit
output

Information sourced from Uniprot.org

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