| Short Description : | Recombinant-Human Glycine N-methyltransferase/GNMT-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications: | SDS-PAGE/Enzyme Activity |
| Host: | E.coli |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Concentration: | 1 mg/mL |
| Formulation: | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 20% Glycerol |
| Storage Instruction: | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
| Endotoxin: | < 1 EU per 1ug of protein (determined by LAL method) |
| Immunoreactivity: | Specific activity is > 100nmol/min/mg, and is defined as the amount of enzyme that transfer 1.0nmole of methyl group per minute at 37C. |
| Gene Symbol: | GNMT |
| Gene ID: | 27232 |
| Uniprot ID: | GNMT_HUMAN |
| Accession Number: | NP_061833 |
| Immunogen: | Human |
| Immunogen Region: | 1-295aa |
| Immunogen Sequence: |
| Tissue Specificity | Expressed only in liver, pancreas, and prostate. |
| Function | Catalyzes the methylation of glycine by using S-adenosylmethionine (AdoMet) to form N-methylglycine (sarcosine) with the concomitant production of S-adenosylhomocysteine (AdoHcy), a reaction regulated by the binding of 5-methyltetrahydrofolate. Plays an important role in the regulation of methyl group metabolism by regulating the ratio between S-adenosyl-L-methionine and S-adenosyl-L-homocysteine. |
| Protein Name | Glycine N-Methyltransferase |
| Database Links | Reactome: R-HSA-2408508Reactome: R-HSA-389661Reactome: R-HSA-9925561 |
| Cellular Localisation | Cytoplasm |
| Alternative Protein Names | Glycine N-Methyltransferase proteinGNMT protein |
Information sourced from Uniprot.org
