Human GLUL protein (Recombinant) (C-His) (STJP014422)

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STJP014422-100
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Host: E.coli
Applications: ELISA/WB
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human GLUL-C-His protein was developed from e.coli and has a target region of C-His. For use in research applications.
Conjugation: Unconjugated
Formulation: Supplied as a 0.22 Mu m filtered solution in 20mM Tris-HCl, 200mM NaCl, 50mM Imidazole, pH 8.0.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt.
Endotoxin: < 1 EU/µg as determined by LAL test.
Gene Symbol: GLUL
Gene ID: 2752
Uniprot ID: GLNA_HUMAN
Immunogen Region: Thr2-Asn373
Immunogen: Homo sapiens (Human)
Post Translational Modifications Acetylated by EP300/p300.acetylation is stimulated by increased glutamine levels and promotes ubiquitin-mediated proteasomal degradation. Palmitoylated.undergoes autopalmitoylation. Ubiquitinated by ZNRF1. Ubiquitinated by the DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex called CRL4(CRBN), leading to proteasomal degradation.
Function Glutamine synthetase that catalyzes the ATP-dependent conversion of glutamate and ammonia to glutamine. Its role depends on tissue localization: in the brain, it regulates the levels of toxic ammonia and converts neurotoxic glutamate to harmless glutamine, whereas in the liver, it is one of the enzymes responsible for the removal of ammonia. Plays a key role in ammonium detoxification during erythropoiesis: the glutamine synthetase activity is required to remove ammonium generated by porphobilinogen deaminase (HMBS) during heme biosynthesis to prevent ammonium accumulation and oxidative stress. Essential for proliferation of fetal skin fibroblasts. Independently of its glutamine synthetase activity, required for endothelial cell migration during vascular development: acts by regulating membrane localization and activation of the GTPase RHOJ, possibly by promoting RHOJ palmitoylation. May act as a palmitoyltransferase for RHOJ: able to autopalmitoylate and then transfer the palmitoyl group to RHOJ. Plays a role in ribosomal 40S subunit biogenesis. Through the interaction with BEST2, inhibits BEST2 channel activity by affecting the gating at the aperture in the absence of intracellular L-glutamate, but sensitizes BEST2 to intracellular L-glutamate, which promotes the opening of BEST2 and thus relieves its inhibitory effect on BEST2.
Protein Name Glutamine Synthetase
Gs
Glutamate--Ammonia Ligase
Palmitoyltransferase Glul
Database Links Reactome: R-HSA-210455
Reactome: R-HSA-8964539
Cellular Localisation Cytoplasm
Cytosol
Microsome
Mitochondrion
Cell Membrane
Lipid-Anchor
Mainly Localizes In The Cytosol
With A Fraction Associated With The Cell Membrane
Alternative Protein Names Glutamine Synthetase protein
Gs protein
Glutamate--Ammonia Ligase protein
Palmitoyltransferase Glul protein
GLUL protein
GLNS protein

Information sourced from Uniprot.org

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