| Host: | Mammalian Cells |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Recombinant-Active-Human GLB1-C-His protein was developed from mammalian cells and has a target region of C-His. For use in research applications. |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol. |
| Dilution Range: | Reconstitute in sterile water for a stock solution. |
| Storage Instruction: | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin: | <0.1 EU/Mu g of the protein by the LAL method. |
| Gene Symbol: | GLB1 |
| Gene ID: | 2720 |
| Uniprot ID: | BGAL_HUMAN |
| Immunogen Region: | Met1-Val677 |
| Immunogen: | Homo sapiens (Human) |
| Function | Isoform 1: Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans. Isoform 2: Has no beta-galactosidase catalytic activity, but plays functional roles in the formation of extracellular elastic fibers (elastogenesis) and in the development of connective tissue. Seems to be identical to the elastin-binding protein (EBP), a major component of the non-integrin cell surface receptor expressed on fibroblasts, smooth muscle cells, chondroblasts, leukocytes, and certain cancer cell types. In elastin producing cells, associates with tropoelastin intracellularly and functions as a recycling molecular chaperone which facilitates the secretions of tropoelastin and its assembly into elastic fibers. |
| Protein Name | Beta-GalactosidaseAcid Beta-GalactosidaseLactaseElastin Receptor 1 |
| Database Links | Reactome: R-HSA-2022857Reactome: R-HSA-2024096Reactome: R-HSA-2206308Reactome: R-HSA-4085001Reactome: R-HSA-4341670Reactome: R-HSA-6798695Reactome: R-HSA-9840310 |
| Cellular Localisation | Isoform 1: LysosomeIsoform 2: CytoplasmPerinuclear RegionLocalized To The Perinuclear Area Of The Cytoplasm But Not To Lysosomes |
| Alternative Protein Names | Beta-Galactosidase proteinAcid Beta-Galactosidase proteinLactase proteinElastin Receptor 1 proteinGLB1 proteinELNR1 protein |
Information sourced from Uniprot.org