Human GITR Ligand/TNFSF18 protein (Recombinant) (His-Tag) (STJP019164)

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STJP019164
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Host: E.coli
Applications: SDS-PAGE
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human GITR Ligand/TNFSF18-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Formulation: Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 10% Glycerol
Concentration: 1 mg/mL
Storage Instruction: For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.
Gene Symbol: TNFSF18
Gene ID: 8995
Uniprot ID: TNF18_HUMAN
Immunogen Region: 72-199aa
Accession Number: NP_005083
Immunogen: Human
Immunogen Sequence: MQLETAKEPC MAKFGPLPSK WQMASSEPPC VNKVSDWKLE ILQNGLYLIY GQVAPNANYN DVAPFEVRLY KNKDMIQTLT NKSKIQNVGG TYELHVGDTI DLIFNSEHQV LKNNTYWGII LIANPQFIS
Tissue Specificity Expressed at high levels in the small intestine, ovary, testis, kidney and endothelial cells.
Function Cytokine that binds to TNFRSF18/AITR/GITR. Regulates T-cell responses. Can function as costimulator and lower the threshold for T-cell activation and T-cell proliferation. Important for interactions between activated T-lymphocytes and endothelial cells. Mediates activation of NF-kappa-B. Triggers increased phosphorylation of STAT1 and up-regulates expression of VCAM1 and ICAM1. Promotes leukocyte adhesion to endothelial cells. Regulates migration of monocytes from the splenic reservoir to sites of inflammation.
Protein Name Tumor Necrosis Factor Ligand Superfamily Member 18
Activation-Inducible Tnf-Related Ligand
Aitrl
Glucocorticoid-Induced Tnf-Related Ligand
Hgitrl
Database Links Reactome: R-HSA-5669034
Cellular Localisation Cell Membrane
Single-Pass Type Ii Membrane Protein
Alternative Protein Names Tumor Necrosis Factor Ligand Superfamily Member 18 protein
Activation-Inducible Tnf-Related Ligand protein
Aitrl protein
Glucocorticoid-Induced Tnf-Related Ligand protein
Hgitrl protein
TNFSF18 protein
AITRL protein
GITRL protein
TL6 protein
UNQ149 protein
PRO175 protein

Information sourced from Uniprot.org

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