Human GHITM protein (Recombinant) (N-His-KSI) (STJP016251)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human GHITM-N-His-KSI protein was developed from e.coli for the region N-His-KSI. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin | Please contact us for further information. |
Target Information
| Gene Symbol | GHITM |
| Gene ID | 27069 |
| Uniprot ID | GHITM_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Leu2-Arg82 |
Additional Info
| Function | Plays an important role in maintenance of mitochondrial morphology and in mediating either calcium or potassium/proton antiport. Mediates proton-dependent calcium efflux from mitochondrion. Also functions as an electroneutral mitochondrial proton/potassium exchanger. Required for the mitochondrial tubular network and cristae organization. Involved in apoptotic release of cytochrome c. Inhibits the proteolytic activity of AFG3L2, stimulating respiration and stabilizing respiratory enzymes in actively respiring mitochondria. However, when mitochondria become hyperpolarized, GHITM loses its inhibitory activity toward AFG3L2 and the now the active AFG3L2 turns first on GHITM and, if hyperpolarization persists, on other proteins of the mitochondria, leading to a broad remodeling of the mitochondrial proteome. |
| Protein Name | Growth Hormone-Inducible Transmembrane ProteinDermal Papilla-Derived Protein 2Mitochondrial Morphology And Cristae Structure 1Mics1Transmembrane Bax Inhibitor Motif-Containing Protein 5 |
| Database Links | |
| Cellular Localisation | Mitochondrion Inner MembraneMulti-Pass Membrane Protein |
| Alternative Protein Names | Growth Hormone-Inducible Transmembrane Protein proteinDermal Papilla-Derived Protein 2 proteinMitochondrial Morphology And Cristae Structure 1 proteinMics1 proteinTransmembrane Bax Inhibitor Motif-Containing Protein 5 proteinGHITM proteinDERP2 proteinMICS1 proteinTMBIM5 proteinMy021 proteinUNQ244 proteinPRO281 protein |
Information sourced from Uniprot.org