Human GGH protein (Recombinant) (His-Tag) (STJP017522)

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STJP017522
£134.50 - £738.50
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Host: E.coli
Applications: SDS-PAGE
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human GGH-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Formulation: Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 1mM DTT, 10% Glycerol, 0.1M NaCl
Concentration: 0.5 mg/mL
Storage Instruction: For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.
Gene Symbol: GGH
Gene ID: 8836
Uniprot ID: GGH_HUMAN
Immunogen Region: 25-318aa
Accession Number: NP_003869.1
Immunogen: Human
Immunogen Sequence: RPHGDTAKK PIIGILMQKC RNKVMKNYGR YYIAASYVKY LESAGARVVP VRLDLTEKDY EILFKSINGI LFPGGSVDLR RSDYAKVAKI FYNLSIQSFD DGDYFPVWGT CLGFEELSLL ISGECLLTAT DTVDVAMPLN FTGGQLHSRM FQNFPTELLL SLAVEPLTAN FHKWSLSVKN FTMNEKLKKF FNVLTTNTDG KIEFIS
Function Hydrolyzes the polyglutamate sidechains of pteroylpolyglutamates. Progressively removes gamma-glutamyl residues from pteroylpoly-gamma-glutamate to yield pteroyl-alpha-glutamate (folic acid) and free glutamate. May play an important role in the bioavailability of dietary pteroylpolyglutamates and in the metabolism of pteroylpolyglutamates and antifolates.
Protein Name Gamma-Glutamyl Hydrolase
Conjugase
Gh
Gamma-Glu-X Carboxypeptidase
Database Links Reactome: R-HSA-6798695
Cellular Localisation Secreted
Extracellular Space
Lysosome
Melanosome
While Its Intracellular Location Is Primarily The Lysosome
Most Of The Enzyme Activity Is Secreted
Identified By Mass Spectrometry In Melanosome Fractions From Stage I To Stage Iv
Alternative Protein Names Gamma-Glutamyl Hydrolase protein
Conjugase protein
Gh protein
Gamma-Glu-X Carboxypeptidase protein
GGH protein

Information sourced from Uniprot.org

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