Human GFER protein (Recombinant) (N-His-SUMO & C-Strep) (STJP007477)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human GFER-N-His-SUMO & C-Strep protein was developed from e.coli for the region N-His-SUMO & C-Strep. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | GFER |
| Gene ID | 2671 |
| Uniprot ID | ALR_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Arg99-Asp205 |
Additional Info
| Function | Isoform 1: FAD-dependent sulfhydryl oxidase that regenerates the redox-active disulfide bonds in CHCHD4/MIA40, a chaperone essential for disulfide bond formation and protein folding in the mitochondrial intermembrane space. The reduced form of CHCHD4/MIA40 forms a transient intermolecular disulfide bridge with GFER/ERV1, resulting in regeneration of the essential disulfide bonds in CHCHD4/MIA40, while GFER/ERV1 becomes re-oxidized by donating electrons to cytochrome c or molecular oxygen. Isoform 2: May act as an autocrine hepatotrophic growth factor promoting liver regeneration. |
| Protein Name | Fad-Linked Sulfhydryl Oxidase AlrAugmenter Of Liver RegenerationHerv1Hepatopoietin |
| Database Links | Reactome: R-HSA-1268020 |
| Cellular Localisation | Isoform 1: Mitochondrion Intermembrane SpaceMitochondrionIsoform 2: CytoplasmSecreted |
| Alternative Protein Names | Fad-Linked Sulfhydryl Oxidase Alr proteinAugmenter Of Liver Regeneration proteinHerv1 proteinHepatopoietin proteinGFER proteinALR proteinHERV1 proteinHPO protein |
Information sourced from Uniprot.org