Human GFER protein (Recombinant) (N-His-SUMO & C-Strep) (STJP007477)

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STJP007477
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Short Description :Recombinant-Human GFER-N-His-SUMO & C-Strep protein was developed from e.coli for the region N-His-SUMO & C-Strep. For use in research applications.
Applications:ELISA/Immunogen/SDS-PAGE/WB
Host:E.coli
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Dilution Range:Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Formulation:Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction:Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol:GFER
Gene ID:2671
Uniprot ID:ALR_HUMAN
Immunogen:Homo sapiens (Human)
Immunogen Region:Arg99-Asp205
Function Isoform 1: FAD-dependent sulfhydryl oxidase that regenerates the redox-active disulfide bonds in CHCHD4/MIA40, a chaperone essential for disulfide bond formation and protein folding in the mitochondrial intermembrane space. The reduced form of CHCHD4/MIA40 forms a transient intermolecular disulfide bridge with GFER/ERV1, resulting in regeneration of the essential disulfide bonds in CHCHD4/MIA40, while GFER/ERV1 becomes re-oxidized by donating electrons to cytochrome c or molecular oxygen. Isoform 2: May act as an autocrine hepatotrophic growth factor promoting liver regeneration.
Protein Name Fad-Linked Sulfhydryl Oxidase Alr
Augmenter Of Liver Regeneration
Herv1
Hepatopoietin
Database Links Reactome: R-HSA-1268020
Cellular Localisation Isoform 1: Mitochondrion Intermembrane Space
Mitochondrion
Isoform 2: Cytoplasm
Secreted
Alternative Protein Names Fad-Linked Sulfhydryl Oxidase Alr protein
Augmenter Of Liver Regeneration protein
Herv1 protein
Hepatopoietin protein
GFER protein
ALR protein
HERV1 protein
HPO protein

Information sourced from Uniprot.org

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