Human GFER/ALR protein (Recombinant) (His-Tag) (STJP017969)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human GFER/ALR-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 0.25 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 0.2M NaCl, 50% Glycerol, 2mM DTT |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | GFER |
| Gene ID | 2671 |
| Uniprot ID | ALR_HUMAN |
| Accession Number | NP_005253 |
| Immunogen | Human |
| Immunogen Region | 1-205aa |
| Immunogen Sequence |
Additional Info
| Tissue Specificity | Ubiquitously expressed. Highest expression in the testis and liver and low expression in the muscle. |
| Function | Isoform 1: FAD-dependent sulfhydryl oxidase that regenerates the redox-active disulfide bonds in CHCHD4/MIA40, a chaperone essential for disulfide bond formation and protein folding in the mitochondrial intermembrane space. The reduced form of CHCHD4/MIA40 forms a transient intermolecular disulfide bridge with GFER/ERV1, resulting in regeneration of the essential disulfide bonds in CHCHD4/MIA40, while GFER/ERV1 becomes re-oxidized by donating electrons to cytochrome c or molecular oxygen. Isoform 2: May act as an autocrine hepatotrophic growth factor promoting liver regeneration. |
| Protein Name | Fad-Linked Sulfhydryl Oxidase AlrAugmenter Of Liver RegenerationHerv1Hepatopoietin |
| Database Links | Reactome: R-HSA-1268020 |
| Cellular Localisation | Isoform 1: Mitochondrion Intermembrane SpaceMitochondrionIsoform 2: CytoplasmSecreted |
| Alternative Protein Names | Fad-Linked Sulfhydryl Oxidase Alr proteinAugmenter Of Liver Regeneration proteinHerv1 proteinHepatopoietin proteinGFER proteinALR proteinHERV1 proteinHPO protein |
Information sourced from Uniprot.org