Human GFER/ALR protein (Recombinant) (His-Tag) (STJP017969)

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STJP017969
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Host: E.coli
Applications: SDS-PAGE
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human GFER/ALR-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Formulation: Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 0.2M NaCl, 50% Glycerol, 2mM DTT
Concentration: 0.25 mg/mL
Storage Instruction: For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.
Gene Symbol: GFER
Gene ID: 2671
Uniprot ID: ALR_HUMAN
Immunogen Region: 1-205aa
Accession Number: NP_005253
Immunogen: Human
Immunogen Sequence: MAAPGE RGRFHGGNLF FLPGGARSEM MDDLATDARG RGAGRRDAAA SASTPAQAPT SDSPVAEDAS RRRPCRACVD FKTWMRTQQK RDTKFREDCP PDREELGRHS WAVLHTLAAY YPDLPTPEQQ QDMAQFIHLF SKFYPCEECA EDLRKRLCRN HPDTRTRACF TQWLCHLHNE VNRKLGKPDF DCSKVDERWR DGWKDG
Tissue Specificity Ubiquitously expressed. Highest expression in the testis and liver and low expression in the muscle.
Function Isoform 1: FAD-dependent sulfhydryl oxidase that regenerates the redox-active disulfide bonds in CHCHD4/MIA40, a chaperone essential for disulfide bond formation and protein folding in the mitochondrial intermembrane space. The reduced form of CHCHD4/MIA40 forms a transient intermolecular disulfide bridge with GFER/ERV1, resulting in regeneration of the essential disulfide bonds in CHCHD4/MIA40, while GFER/ERV1 becomes re-oxidized by donating electrons to cytochrome c or molecular oxygen. Isoform 2: May act as an autocrine hepatotrophic growth factor promoting liver regeneration.
Protein Name Fad-Linked Sulfhydryl Oxidase Alr
Augmenter Of Liver Regeneration
Herv1
Hepatopoietin
Database Links Reactome: R-HSA-1268020
Cellular Localisation Isoform 1: Mitochondrion Intermembrane Space
Mitochondrion
Isoform 2: Cytoplasm
Secreted
Alternative Protein Names Fad-Linked Sulfhydryl Oxidase Alr protein
Augmenter Of Liver Regeneration protein
Herv1 protein
Hepatopoietin protein
GFER protein
ALR protein
HERV1 protein
HPO protein

Information sourced from Uniprot.org

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