Human GET3 protein (Recombinant) (N-His) (STJP008329)

Name: Human GET3 protein (Recombinant) (N-His) (STJP008329)
SKU: STJP008329
Availability: InStock

⇓ Datasheet ⇓ SDS

SPECIFICATIONS

HostE.coli

ImmunogenHomo sapiens (Human)

STJP008329

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Short Description	Recombinant-Human GET3-N-His protein was developed from e.coli for the region N-His. For use in research applications.
Applications	ELISA/Immunogen/SDS-PAGE/WB
Host	E.coli
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Dilution Range	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Formulation	Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.

Function	ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors GET1/WRB and CAMLG/GET2, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the GET1-CAMLG receptor, and returning it to the cytosol to initiate a new round of targeting. May be involved in insulin signaling.
Protein Name	Atpase Get3 Arsenical Pump-Driving Atpase Arsenite-Stimulated Atpase Guided Entry Of Tail-Anchored Proteins Factor 3 - Atpase Transmembrane Domain Recognition Complex 40 Kda Atpase Subunit Harsa-I Hasna-I
Database Links	Reactome: R-HSA-9609523
Cellular Localisation	Cytoplasm Endoplasmic Reticulum Nucleus Nucleolus
Alternative Protein Names	Atpase Get3 protein Arsenical Pump-Driving Atpase protein Arsenite-Stimulated Atpase protein Guided Entry Of Tail-Anchored Proteins Factor 3 - Atpase protein Transmembrane Domain Recognition Complex 40 Kda Atpase Subunit protein Harsa-I protein Hasna-I protein GET3 protein ARSA protein ASNA1 protein TRC40 protein

Information sourced from Uniprot.org