Human GDNFR alpha-3/GFRA3 protein (Recombinant) (His-Tag) (STJP018499)

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STJP018499
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Host: E.coli
Applications: SDS-PAGE/Denatured
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human GDNFR alpha-3/GFRA3-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Formulation: Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 10% Glycerol 0.4M urea
Concentration: 1 mg/mL
Storage Instruction: For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.
Gene Symbol: GFRA3
Gene ID: 2676
Uniprot ID: GFRA3_HUMAN
Immunogen Region: 32-374aa
Accession Number: NP_001487
Immunogen: Human
Immunogen Sequence: MGSSHHHHHH SSGLVPRGSH MGSDPLPTES RLMNSCLQAR RKCQADPTCS AAYHHLDSCT SSISTPLPSE EPSVPADCLE AAQQLRNSSL IGCMCHRRMK NQVACLDIYW TVHRARSLGN YELDVSPYED TVTSKPWKMN LSKLNMLKPD SDLCLKFAML CTLNDKCDRL RKAYGEACSG PHCQRHVCLR QLLTFFEKAA EPHAQGLLLC PCAPNDRGCG ERRRNTIA
Tissue Specificity Widely expressed in adult and fetus which exhibit a similar pattern. Essentially not expressed in the central nervous system, but highly expressed in several sensory and sympathetic ganglia of the peripheral nervous system. Moderate expression in many non-neuronal tissues, particularly those of the digestive and urogenital systems, but high expression in stomach and appendix. Several types of glandular tissues show low expression. Very low or no expression detected in the hematopoietic system.
Post Translational Modifications N-glycosylated.
Function Receptor for artemin (ARTN), a growth factor that supports the survival of sensory and sympathetic peripheral neurons. ARTN-binding leads to autophosphorylation and activation of the RET receptor.
Protein Name Gdnf Family Receptor Alpha-3
Gdnf Receptor Alpha-3
Gdnfr-Alpha-3
Gfr-Alpha-3
Database Links Reactome: R-HSA-5673001
Reactome: R-HSA-8853659
Cellular Localisation Cell Membrane
Lipid-Anchor
Gpi-Anchor
Alternative Protein Names Gdnf Family Receptor Alpha-3 protein
Gdnf Receptor Alpha-3 protein
Gdnfr-Alpha-3 protein
Gfr-Alpha-3 protein
GFRA3 protein
UNQ339 protein
PRO538 protein
PRO3664 protein

Information sourced from Uniprot.org

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