| Host: |
HEK293 cells |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Formulation: |
Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method: |
< 1.0 EU/Mu g of the protein by LAL method. |
| Immunoreactivity: |
Measured by its binding ability in a functional ELISA. Immobilized Human GDNF at 1 Mu g/mL (100 Mu L/well) can bind Human GFRA1 with a linear range of 2-332 ng/mL. |
| Gene Symbol: |
GFRA1 |
| Gene ID: |
2674 |
| Uniprot ID: |
GFRA1_HUMAN |
| Immunogen: |
Recombinant Human GDNFR-alpha-1/GFRA1 Protein is produced by HEK293 expression system. The target protein is expressed with sequence (Ala19-Lys429) of human GFRA1/GFR Alpha 1/GDNFRA (Accession #NP_665736) fused with an Fc, 6×His tag at the C-terminus |
| Immunogen Sequence: |
AEVSGGDRLDCVKASDQCLK EQSCSTKYRTLRQCVAGKET NFSLASGLEAKDECRSAMEA LKQKSLYNCRCKRGMKKEKN CLRIYWSMYQSLQGNDLLED SPYEPVNSRLSDIFRVVPFI SVEHIPKGNNCLDAAKACNL DDICKKYRSAYITPCTTSVS NDVCNRRKCHKALRQFFDKV PAKHSYGMLFCSCRDIACTE RRRQTIVPVCSYEEREKPNC LNLQDSCKTNYICRSRLAD |
| Function | Coreceptor for GDNF, a neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake. GDNF-binding leads to autophosphorylation and activation of the RET receptor. |
| Protein Name | Gdnf Family Receptor Alpha-1Gdnf Receptor Alpha-1Gdnfr-Alpha-1Gfr-Alpha-1Ret Ligand 1Tgf-Beta-Related Neurotrophic Factor Receptor 1 |
| Database Links | Reactome: R-HSA-419037Reactome: R-HSA-5673001Reactome: R-HSA-8853659Reactome: R-HSA-9830674 |
| Cellular Localisation | Cell MembraneLipid-AnchorGpi-AnchorGolgi ApparatusTrans-Golgi NetworkEndosomeMultivesicular BodyLocalizes Mainly To The Plasma MembraneIn The Presence Of Sorl1Shifts To Vesicular StructuresIncluding Trans-Golgi NetworkEndosomes And Multivesicular Bodies |
| Alternative Protein Names | Gdnf Family Receptor Alpha-1 proteinGdnf Receptor Alpha-1 proteinGdnfr-Alpha-1 proteinGfr-Alpha-1 proteinRet Ligand 1 proteinTgf-Beta-Related Neurotrophic Factor Receptor 1 proteinGFRA1 proteinGDNFRA proteinRETL1 proteinTRNR1 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
