| Post Translational Modifications | Isoprenylation is required for proper subcellular location. |
| Function | Interferon (IFN)-inducible GTPase that plays important roles in innate immunity against a diverse range of bacterial, viral and protozoan pathogens. Hydrolyzes GTP, but in contrast to other family members, does not produce GMP. Following infection, recruited to the pathogen-containing vacuoles or vacuole-escaped bacteria and acts as a positive regulator of inflammasome assembly by promoting the release of inflammasome ligands from bacteria. Acts by promoting lysis of pathogen-containing vacuoles, releasing pathogens into the cytosol. Following pathogen release in the cytosol, promotes recruitment of proteins that mediate bacterial cytolysis: this liberates ligands that are detected by inflammasomes, such as lipopolysaccharide (LPS) that activates the non-canonical CASP4/CASP11 inflammasome or double-stranded DNA (dsDNA) that activates the AIM2 inflammasome. As an activator of NLRP3 inflammasome assembly: promotes selective NLRP3 inflammasome assembly in response to microbial and soluble, but not crystalline, agents. Independently of its GTPase activity, acts as an inhibitor of various viruses infectivity, such as HIV-1, Zika and influenza A viruses, by inhibiting FURIN-mediated maturation of viral envelope proteins. Antigenic tumor-specific truncated splice form. |
| Protein Name | Guanylate-Binding Protein 5Gbp-Ta AntigenGtp-Binding Protein 5Gbp-5Guanine Nucleotide-Binding Protein 5 |
| Database Links | Reactome: R-HSA-877300 |
| Cellular Localisation | Cytoplasmic Vesicle MembraneLipid-AnchorGpi-Like-AnchorGolgi Apparatus MembraneCytoplasm |
| Alternative Protein Names | Guanylate-Binding Protein 5 proteinGbp-Ta Antigen proteinGtp-Binding Protein 5 proteinGbp-5 proteinGuanine Nucleotide-Binding Protein 5 proteinGBP5 proteinUNQ2427 proteinPRO4987 protein |
Information sourced from Uniprot.org
