Human GARS1 protein (Recombinant) (N-His) (STJP004700)

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STJP004700
€410.63 - €1,796.88
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human GARS1-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: GARS1
Gene ID: 2617
Uniprot ID: GARS_HUMAN
Immunogen Region: Val567-Lys734
Immunogen: Homo sapiens (Human)
Function Catalyzes the ATP-dependent ligation of glycine to the 3'-end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (Gly-AMP). Also produces diadenosine tetraphosphate (Ap4A), a universal pleiotropic signaling molecule needed for cell regulation pathways, by direct condensation of 2 ATPs. Thereby, may play a special role in Ap4A homeostasis.
Protein Name Glycine--Trna Ligase
Diadenosine Tetraphosphate Synthetase
Ap4a Synthetase
Glycyl-Trna Synthetase
Glyrs
Glycyl-Trna Synthetase 1
Database Links Reactome: R-HSA-379716
Reactome: R-HSA-379726
Cellular Localisation Cytoplasm
Cell Projection
Axon
Secreted
Extracellular Exosome
In Transfected Cos7 Cells
Not Detected In Mitochondria
Nor In Golgi Apparatus
Secreted By Motor Neuron
Possibly Through The Exosome Pathway
Isoform 1: Mitochondrion
Isoform 2: Cytoplasm
Alternative Protein Names Glycine--Trna Ligase protein
Diadenosine Tetraphosphate Synthetase protein
Ap4a Synthetase protein
Glycyl-Trna Synthetase protein
Glyrs protein
Glycyl-Trna Synthetase 1 protein
GARS1 protein
GARS protein

Information sourced from Uniprot.org

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