Human GARS protein (Recombinant) (His-Tag) (STJP018852)

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STJP018852
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Host: E.coli
Applications: SDS-PAGE
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human GARS-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Formulation: Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 10% Glycerol, 1mM DTT
Concentration: 0.5 mg/mL
Storage Instruction: For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.
Gene Symbol: GARS1
Gene ID: 2617
Uniprot ID: GARS_HUMAN
Immunogen Region: 43-289aa
Accession Number: NP_002038
Immunogen: Human
Immunogen Sequence: PISLPAA ASRSSMDGAG AEEVLAPLRL AVRQQGDLVR KLKEDKAPQV DVDKAVAELK ARKRVLEAKE LALQPKDDIV DRAKMEDTLK RRFFYDQAFA IYGGVSGLYD FGPVGCALKN NIIQTWRQHF IQEEQILEID CTMLTPEPVL KTSGHVDKFA DFMVKDVKNG ECFRADHLLK AHLQKLMSDK KCSVEKKSEM ESVLAQ
Tissue Specificity Widely expressed, including in brain and spinal cord. Isoform 2: Expressed in brain, spinal cord, muscle, heart and spleen. Isoform 1: Expressed in brain, spinal cord, muscle, heart, spleen and liver.
Function Catalyzes the ATP-dependent ligation of glycine to the 3'-end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (Gly-AMP). Also produces diadenosine tetraphosphate (Ap4A), a universal pleiotropic signaling molecule needed for cell regulation pathways, by direct condensation of 2 ATPs. Thereby, may play a special role in Ap4A homeostasis.
Protein Name Glycine--Trna Ligase
Diadenosine Tetraphosphate Synthetase
Ap4a Synthetase
Glycyl-Trna Synthetase
Glyrs
Glycyl-Trna Synthetase 1
Database Links Reactome: R-HSA-379716
Reactome: R-HSA-379726
Cellular Localisation Cytoplasm
Cell Projection
Axon
Secreted
Extracellular Exosome
In Transfected Cos7 Cells
Not Detected In Mitochondria
Nor In Golgi Apparatus
Secreted By Motor Neuron
Possibly Through The Exosome Pathway
Isoform 1: Mitochondrion
Isoform 2: Cytoplasm
Alternative Protein Names Glycine--Trna Ligase protein
Diadenosine Tetraphosphate Synthetase protein
Ap4a Synthetase protein
Glycyl-Trna Synthetase protein
Glyrs protein
Glycyl-Trna Synthetase 1 protein
GARS1 protein
GARS protein

Information sourced from Uniprot.org

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