Human Galectin-8/GAL8 protein (Recombinant-Active) (Tag free) (STJP012341)

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STJP012341-100
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Short Description :Recombinant-Active-Human Galectin-8/GAL8-Tag free protein was developed from e.coli and has a target region of Tag free. For use in research applications.
Applications:ELISA/WB
Host:E.coli
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Conjugation:Unconjugated
Dilution Range:Reconstitute in sterile water for a stock solution.
Formulation:Lyophilized from a 0.22 Mu m filtered solution in PBS, pH 7.4.
Storage Instruction:Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt.
Endotoxin:< 1 EU/µg as determined by LAL test.
Gene Symbol:LGALS8
Gene ID:3964
Uniprot ID:LEG8_HUMAN
Immunogen:Homo sapiens (Human)
Immunogen Region:Met1-Trp317
Function Beta-galactoside-binding lectin that acts as a sensor of membrane damage caused by infection and restricts the proliferation of infecting pathogens by targeting them for autophagy. Detects membrane rupture by binding beta-galactoside ligands located on the lumenal side of the endosome membrane.these ligands becoming exposed to the cytoplasm following rupture. Restricts infection by initiating autophagy via interaction with CALCOCO2/NDP52. Required to restrict infection of bacterial invasion such as S.typhimurium. Also required to restrict infection of Picornaviridae viruses. Has a marked preference for 3'-O-sialylated and 3'-O-sulfated glycans.
Protein Name Galectin-8
Gal-8
Po66 Carbohydrate-Binding Protein
Po66-Cbp
Prostate Carcinoma Tumor Antigen 1
Pcta-1
Database Links
Cellular Localisation Cytoplasmic Vesicle
Cytoplasm
Cytosol
Alternative Protein Names Galectin-8 protein
Gal-8 protein
Po66 Carbohydrate-Binding Protein protein
Po66-Cbp protein
Prostate Carcinoma Tumor Antigen 1 protein
Pcta-1 protein
LGALS8 protein

Information sourced from Uniprot.org

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