Human GAK protein (Recombinant) (C-His) (STJP014257)

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STJP014257-100
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Short Description :Recombinant-Human GAK-C-His protein was developed from e.coli and has a target region of C-His. For use in research applications.
Applications:ELISA/WB
Host:E.coli
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Conjugation:Unconjugated
Dilution Range:Reconstitute in sterile water for a stock solution.
Formulation:Lyophilized from a solution in PBS pH 7.4, 0.02% SKL, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction:Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Endotoxin:Please contact us for this information.
Gene Symbol:GAK
Gene ID:2580
Uniprot ID:GAK_HUMAN
Immunogen:Homo sapiens (Human)
Immunogen Region:Pro14-Val351
Function Associates with cyclin G and CDK5. Seems to act as an auxilin homolog that is involved in the uncoating of clathrin-coated vesicles by Hsc70 in non-neuronal cells. Expression oscillates slightly during the cell cycle, peaking at G1. May play a role in clathrin-mediated endocytosis and intracellular trafficking, and in the dynamics of clathrin assembly/disassembly.
Protein Name Cyclin-G-Associated Kinase
Dnaj Homolog Subfamily C Member 26
Database Links Reactome: R-HSA-432722
Reactome: R-HSA-8856828
Cellular Localisation Cytoplasm
Perinuclear Region
Golgi Apparatus
Trans-Golgi Network
Cell Junction
Focal Adhesion
Cytoplasmic Vesicle
Clathrin-Coated Vesicle
Localizes To The Perinuclear Area And To The Trans-Golgi Network
Also Seen On The Plasma Membrane
Probably At Focal Adhesions
Recruitment To Clathrin-Coated Vesicles Depends On Temporal Variations In Phosphoinositide Composition Of Clathrin-Coated Vesicles
Alternative Protein Names Cyclin-G-Associated Kinase protein
Dnaj Homolog Subfamily C Member 26 protein
GAK protein
DNAJC26 protein

Information sourced from Uniprot.org

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