| Function | Acts as a negative regulator of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but occurs also in the absence of GADD45 proteins. Acts as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity. May be involved in the hormone-mediated regulation of NR4A1 transcriptional activity. May play a role in mitochondrial protein synthesis. |
| Protein Name | Large Ribosomal Subunit Protein Ml6439s Ribosomal Protein L59 - MitochondrialMrp-L59Ckii Beta-Associating ProteinCr6-Interacting Factor 1Crif1Growth Arrest And Dna Damage-Inducible Proteins-Interacting Protein 1Papillomavirus L2-Interacting Nuclear Protein 1PlinpPlinp-1P53-Responsive Gene 6 Protein |
| Database Links | Reactome: R-HSA-5368286Reactome: R-HSA-5389840Reactome: R-HSA-5419276 |
| Cellular Localisation | MitochondrionNucleusUsing N-Terminally Tagged ConstructsHas Been Found In The NucleusC-Terminally Tagged Constructs Are Targeted Exclusively To MitochondriaThis Discrepancy May Be Explained By Masking Of A Potential N-Terminal Mitochondrial Targeting Signal By The Tag |
| Alternative Protein Names | Large Ribosomal Subunit Protein Ml64 protein39s Ribosomal Protein L59 - Mitochondrial proteinMrp-L59 proteinCkii Beta-Associating Protein proteinCr6-Interacting Factor 1 proteinCrif1 proteinGrowth Arrest And Dna Damage-Inducible Proteins-Interacting Protein 1 proteinPapillomavirus L2-Interacting Nuclear Protein 1 proteinPlinp proteinPlinp-1 proteinP53-Responsive Gene 6 Protein proteinGADD45GIP1 proteinMRPL59 proteinPLINP1 proteinPRG6 protein |
Information sourced from Uniprot.org
