| Tissue Specificity | Widely expressed. Highly expressed in the thyroid gland, heart, lymph nodes, trachea and adrenal tissues. Expressed at lower level in liver skeletal muscle, kidney, pancreas, testis, ovary and stomach. Barely detectable in adrenal adenoma and papillary thyroid cancer. |
| Function | Acts as a negative regulator of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but also occur in the absence of GADD45 proteins. Acts as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity. May be involved in the hormone-mediated regulation of NR4A1 transcriptional activity. May play a role in mitochondrial protein synthesis. |
| Protein Name | Large Ribosomal Subunit Protein Ml6439s Ribosomal Protein L59 - MitochondrialMrp-L59Ckii Beta-Associating ProteinCr6-Interacting Factor 1Crif1Growth Arrest And Dna Damage-Inducible Proteins-Interacting Protein 1Papillomavirus L2-Interacting Nuclear Protein 1PlinpPlinp-1P53-Responsive Gene 6 Protein |
| Database Links | Reactome: R-HSA-5368286Reactome: R-HSA-5389840Reactome: R-HSA-5419276 |
| Cellular Localisation | MitochondrionNucleusUsing N-Terminally Tagged ConstructsHas Been Found In The NucleusC-Terminally Tagged Constructs Are Targeted Exclusively To MitochondriaThis Discrepancy May Be Explained By Masking Of A Potential N-Terminal Mitochondrial Targeting Signal By The Tag |
| Alternative Protein Names | Large Ribosomal Subunit Protein Ml64 protein39s Ribosomal Protein L59 - Mitochondrial proteinMrp-L59 proteinCkii Beta-Associating Protein proteinCr6-Interacting Factor 1 proteinCrif1 proteinGrowth Arrest And Dna Damage-Inducible Proteins-Interacting Protein 1 proteinPapillomavirus L2-Interacting Nuclear Protein 1 proteinPlinp proteinPlinp-1 proteinP53-Responsive Gene 6 Protein proteinGADD45GIP1 proteinMRPL59 proteinPLINP1 proteinPRG6 protein |
Information sourced from Uniprot.org
