| Post Translational Modifications | Acetylated. Deacetylated by SIRT2 at Lys-69 and Lys-159.deacetylation enhances the interaction of FZR1 with CDC27, leading to activation of anaphase promoting complex/cyclosome (APC/C). Following DNA damage, it is dephosphorylated by CDC14B in G2 phase, leading to its reassociation with the APC/C, and allowing an efficient G2 DNA damage checkpoint. Phosphorylated by MAK. Ubiquitinated by the SCF(CCNF) E3 ubiquitin-protein ligase complex.leading to its degradation by the proteasome. |
| Function | Substrate-specific adapter for the anaphase promoting complex/cyclosome (APC/C) E3 ubiquitin-protein ligase complex. Associates with the APC/C in late mitosis, in replacement of CDC20, and activates the APC/C during anaphase and telophase. The APC/C remains active in degrading substrates to ensure that positive regulators of the cell cycle do not accumulate prematurely. At the G1/S transition FZR1 is phosphorylated, leading to its dissociation from the APC/C. Following DNA damage, it is required for the G2 DNA damage checkpoint: its dephosphorylation and reassociation with the APC/C leads to the ubiquitination of PLK1, preventing entry into mitosis. Acts as an adapter for APC/C to target the DNA-end resection factor RBBP8/CtIP for ubiquitination and subsequent proteasomal degradation. Through the regulation of RBBP8/CtIP protein turnover, may play a role in DNA damage response, favoring DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR). |
| Protein Name | Fizzy-Related Protein HomologFzrCdc20-Like Protein 1Cdh1/Hct1 HomologHcdh1 |
| Database Links | Reactome: R-HSA-174084Reactome: R-HSA-174113Reactome: R-HSA-174178Reactome: R-HSA-176407Reactome: R-HSA-176408Reactome: R-HSA-176417Reactome: R-HSA-2559582Reactome: R-HSA-68867Reactome: R-HSA-69017Reactome: R-HSA-69656Reactome: R-HSA-8853884Reactome: R-HSA-9687136Reactome: R-HSA-983168 |
| Cellular Localisation | Isoform 2: NucleusIsoform 3: Cytoplasm |
| Alternative Protein Names | Fizzy-Related Protein Homolog proteinFzr proteinCdc20-Like Protein 1 proteinCdh1/Hct1 Homolog proteinHcdh1 proteinFZR1 proteinCDH1 proteinFYR proteinFZR proteinKIAA1242 protein |
Information sourced from Uniprot.org
