Human FXYD1 protein (Recombinant) (N-GST & C-His) (STJP007465)

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STJP007465
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human FXYD1-N-GST & C-His protein was developed from e. coli and has a target region of N-GST & C-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: FXYD1
Gene ID: 5348
Uniprot ID: PLM_HUMAN
Immunogen Region: Glu21-Arg92
Immunogen: Homo sapiens (Human)
Post Translational Modifications Major plasma membrane substrate for cAMP-dependent protein kinase (PKA) and protein kinase C (PKC) in several different tissues. Phosphorylated in response to insulin and adrenergic stimulation. Phosphorylation at Ser-88 stimulates sodium/potassium-transporting ATPase activity while the unphosphorylated form inhibits sodium/potassium-transporting ATPase activity. Phosphorylation increases tetramerization, decreases binding to ATP1A1 and reduces inhibition of ATP1A1 activity. Phosphorylation at Ser-83 leads to greatly reduced interaction with ATP1A1, ATP1A2 and ATP1A3. May be phosphorylated by DMPK. Palmitoylation increases half-life and stability and is enhanced upon phosphorylation at Ser-88 by PKA.
Function Associates with and regulates the activity of the sodium/potassium-transporting ATPase (NKA) which transports Na(+) out of the cell and K(+) into the cell. Inhibits NKA activity in its unphosphorylated state and stimulates activity when phosphorylated. Reduces glutathionylation of the NKA beta-1 subunit ATP1B1, thus reversing glutathionylation-mediated inhibition of ATP1B1. Contributes to female sexual development by maintaining the excitability of neurons which secrete gonadotropin-releasing hormone.
Protein Name Phospholemman
Fxyd Domain-Containing Ion Transport Regulator 1
Sodium/Potassium-Transporting Atpase Subunit Fxyd1
Database Links Reactome: R-HSA-5578775
Reactome: R-HSA-936837
Reactome: R-HSA-9679191
Cellular Localisation Cell Membrane
Sarcolemma
Single-Pass Type I Membrane Protein
Apical Cell Membrane
Membrane
Caveola
T-Tubule
Detected In The Apical Cell Membrane In Brain
In Myocytes
Localizes To Sarcolemma
T-Tubules And Intercalated Disks
Alternative Protein Names Phospholemman protein
Fxyd Domain-Containing Ion Transport Regulator 1 protein
Sodium/Potassium-Transporting Atpase Subunit Fxyd1 protein
FXYD1 protein
PLM protein

Information sourced from Uniprot.org

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