Human FXYD1 protein (Recombinant) (N-GST & C-His) (STJP007465)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human FXYD1-N-GST & C-His protein was developed from e.coli for the region N-GST & C-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | FXYD1 |
| Gene ID | 5348 |
| Uniprot ID | PLM_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Glu21-Arg92 |
Additional Info
| Post Translational Modifications | Major plasma membrane substrate for cAMP-dependent protein kinase (PKA) and protein kinase C (PKC) in several different tissues. Phosphorylated in response to insulin and adrenergic stimulation. Phosphorylation at Ser-88 stimulates sodium/potassium-transporting ATPase activity while the unphosphorylated form inhibits sodium/potassium-transporting ATPase activity. Phosphorylation increases tetramerization, decreases binding to ATP1A1 and reduces inhibition of ATP1A1 activity. Phosphorylation at Ser-83 leads to greatly reduced interaction with ATP1A1, ATP1A2 and ATP1A3. May be phosphorylated by DMPK. Palmitoylation increases half-life and stability and is enhanced upon phosphorylation at Ser-88 by PKA. |
| Function | Associates with and regulates the activity of the sodium/potassium-transporting ATPase (NKA) which transports Na(+) out of the cell and K(+) into the cell. Inhibits NKA activity in its unphosphorylated state and stimulates activity when phosphorylated. Reduces glutathionylation of the NKA beta-1 subunit ATP1B1, thus reversing glutathionylation-mediated inhibition of ATP1B1. Contributes to female sexual development by maintaining the excitability of neurons which secrete gonadotropin-releasing hormone. |
| Protein Name | PhospholemmanFxyd Domain-Containing Ion Transport Regulator 1Sodium/Potassium-Transporting Atpase Subunit Fxyd1 |
| Database Links | Reactome: R-HSA-5578775Reactome: R-HSA-936837Reactome: R-HSA-9679191 |
| Cellular Localisation | Cell MembraneSarcolemmaSingle-Pass Type I Membrane ProteinApical Cell MembraneMembraneCaveolaT-TubuleDetected In The Apical Cell Membrane In BrainIn MyocytesLocalizes To SarcolemmaT-Tubules And Intercalated Disks |
| Alternative Protein Names | Phospholemman proteinFxyd Domain-Containing Ion Transport Regulator 1 proteinSodium/Potassium-Transporting Atpase Subunit Fxyd1 proteinFXYD1 proteinPLM protein |
Information sourced from Uniprot.org