| Function | Catalyzes the transfer of L-fucose, from a guanosine diphosphate-beta-L-fucose, to the terminal galactose on both O- and N-linked glycans chains of cell surface glycoproteins and glycolipids and the resulting epitope regulates several processes such as cell-cell interaction including host-microbe interaction, cell surface expression and cell proliferation. Preferentially fucosylates gangliosides GA1 and GM1 in the antrum, cecum and colon and in the female reproductive organs. Fucosylated host glycoproteins or glycolipids mediate interaction with intestinal microbiota influencing its composition. Creates a soluble precursor oligosaccharide FuC-alpha ((1,2)Galbeta-) called the H antigen which is an essential substrate for the final step in the soluble ABO blood group antigen synthesis pathway. |
| Protein Name | Galactoside Alpha-(1 -2-Fucosyltransferase 2Alpha(1 -2ft 2Fucosyltransferase 2Gdp-L-Fucose -Beta-D-Galactoside 2-Alpha-L-Fucosyltransferase 2Se2Secretor Blood Group Alpha-2-FucosyltransferaseSecretor FactorSeType 1 Galactoside Alpha-(1 -2-Fucosyltransferase Fut2Type 2 Galactoside Alpha-(1 -2-Fucosyltransferase Fut2 |
| Database Links | Reactome: R-HSA-9033807Reactome: R-HSA-9037629Reactome: R-HSA-9840309 |
| Cellular Localisation | Golgi ApparatusGolgi Stack MembraneSingle-Pass Type Ii Membrane ProteinMembrane-Bound Form In Trans Cisternae Of Golgi |
| Alternative Protein Names | Galactoside Alpha-(1 -2-Fucosyltransferase 2 proteinAlpha(1 -2ft 2 proteinFucosyltransferase 2 proteinGdp-L-Fucose -Beta-D-Galactoside 2-Alpha-L-Fucosyltransferase 2 proteinSe2 proteinSecretor Blood Group Alpha-2-Fucosyltransferase proteinSecretor Factor proteinSe proteinType 1 Galactoside Alpha-(1 -2-Fucosyltransferase Fut2 proteinType 2 Galactoside Alpha-(1 -2-Fucosyltransferase Fut2 proteinFUT2 proteinSEC2 protein |
Information sourced from Uniprot.org
