| Tissue Specificity | Strongly expressed in heart and skeletal muscle, followed by brain and pancreas, with weak expression in kidney, liver, and lung and no expression in placenta. |
| Function | N-alpha-acetyltransferase that specifically mediates the acetylation of the acidic amino terminus of processed forms of beta- and gamma-actin (ACTB and ACTG, respectively). N-terminal acetylation of processed beta- and gamma-actin regulates actin filament depolymerization and elongation. In vivo, preferentially displays N-terminal acetyltransferase activity towards acid N-terminal sequences starting with Asp-Asp-Asp and Glu-Glu-Glu. In vitro, shows high activity towards Met-Asp-Glu-Leu and Met-Asp-Asp-Asp. May act as a tumor suppressor. |
| Protein Name | N-Alpha-Acetyltransferase 80Hsnaaa80N-Acetyltransferase 6Protein Fusion-2Protein Fus-2 |
| Database Links | |
| Cellular Localisation | CytoplasmCytosol |
| Alternative Protein Names | N-Alpha-Acetyltransferase 80 proteinHsnaaa80 proteinN-Acetyltransferase 6 proteinProtein Fusion-2 proteinProtein Fus-2 proteinNAA80 proteinFUS2 proteinNAT6 protein |
Information sourced from Uniprot.org
