| Tissue Specificity | Highly expressed in stomach, colon, small intestine, lung and kidney and to a lesser extent in salivary gland, bladder, uterus and liver. |
| Post Translational Modifications | Glycosylated. |
| Function | Catalyzes the transfer of L-fucose, from a guanosine diphosphate-beta-L-fucose, to both the subterminal N-acetyl glucosamine (GlcNAc) of type 1 chain (beta-D-Gal-(1->3)-beta-D-GlcNAc) glycolipids and oligosaccharides via an alpha(1,4) linkage, and the subterminal glucose (Glc) or GlcNAc of type 2 chain (beta-D-Gal-(1->4)-beta-D-GlcNAc) oligosaccharides via an alpha(1,3) linkage, independently of the presence of terminal alpha-L-fucosyl-(1,2) moieties on the terminal galactose of these acceptors. Through its catalytic activity, participates in the synthesis of antigens of the Lewis blood group system, i.e. Lewis a (Le(a)), lewis b (Le(b)), Lewis x/SSEA-1 (Le(x)) and lewis y (Le(y)) antigens. Also catalyzes the transfer of L-fucose to subterminal GlcNAc of sialyl- and disialyl-lactotetraosylceramide to produce sialyl Lewis a (sLe(a)) and disialyl Lewis a via an alpha(1,4) linkage and therefore may regulate cell surface sLe(a) expression and consequently regulates adhesive properties to E-selectin, cell proliferation and migration. Catalyzes the transfer of an L-fucose to 3'-sialyl-N-acetyllactosamine by an alpha(1,3) linkage, which allows the formation of sialyl-Lewis x structure and therefore may regulate the sialyl-Lewis x surface antigen expression and consequently adhesive properties to E-selectin. Prefers type 1 chain over type 2 acceptors. Type 1 tetrasaccharide is a better acceptor than type 1 disaccharide suggesting that a beta anomeric configuration of GlcNAc in the substrate is preferred. Lewis-positive (Le(+)) individuals have an active enzyme while Lewis-negative (Le(-)) individuals have an inactive enzyme. |
| Protein Name | 3-Galactosyl-N-Acetylglucosaminide 4-Alpha-L-Fucosyltransferase Fut34-Galactosyl-N-Acetylglucosaminide 3-Alpha-L-FucosyltransferaseAlpha-3-Fucosyltransferase Fut3Blood Group Lewis Alpha-4-FucosyltransferaseLewis FtFucosyltransferase 3Fucosyltransferase IiiFuct-Iii |
| Database Links | Reactome: R-HSA-9037629Reactome: R-HSA-975578 |
| Cellular Localisation | Golgi ApparatusGolgi Stack MembraneSingle-Pass Type Ii Membrane ProteinMembrane-Bound Form In Trans Cisternae Of Golgi |
| Alternative Protein Names | 3-Galactosyl-N-Acetylglucosaminide 4-Alpha-L-Fucosyltransferase Fut3 protein4-Galactosyl-N-Acetylglucosaminide 3-Alpha-L-Fucosyltransferase proteinAlpha-3-Fucosyltransferase Fut3 proteinBlood Group Lewis Alpha-4-Fucosyltransferase proteinLewis Ft proteinFucosyltransferase 3 proteinFucosyltransferase Iii proteinFuct-Iii proteinFUT3 proteinFT3B proteinLE protein |
Information sourced from Uniprot.org
