| Tissue Specificity | Widely expressed, with highest expression in muscle, placenta, and heart. |
| Function | S-adenosyl-L-methionine-dependent 2'-O-ribose methyltransferase that catalyzes the formation of 2'-O-methyluridine at position 1369 (Um1369) in the 16S mitochondrial large subunit ribosomal RNA (mtLSU rRNA), a universally conserved modification in the peptidyl transferase domain of the mtLSU rRNA. This activity may require prior 2'-O-methylguanosine modification at position 1370 (Gm1370) by MRM3. Essential for late-stage assembly of mtLSU required for efficient translation of mitochondrial DNA encoded proteins.methyltransferase activity is not required for this function. Essential for mitochondrial respiratory function. |
| Protein Name | Rrna Methyltransferase 2 - Mitochondrial16s RrnaUridine(1369-2'-O-Methyltransferase16s Rrna Um1369 2'-O-MethyltransferaseProtein Ftsj Homolog 2 |
| Database Links | Reactome: R-HSA-6793080 |
| Cellular Localisation | Mitochondrion |
| Alternative Protein Names | Rrna Methyltransferase 2 - Mitochondrial protein16s Rrna proteinUridine(1369-2'-O-Methyltransferase protein16s Rrna Um1369 2'-O-Methyltransferase proteinProtein Ftsj Homolog 2 proteinMRM2 proteinFJH1 proteinFTSJ2 protein |
Information sourced from Uniprot.org
