Human FSTL3/FLRG protein (Recombinant-Active) (C-His) (STJP011756)

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STJP011756-100
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Host: Mammalian Cells
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Active-Human FSTL3/FLRG-C-His protein was developed from mammalian cells and has a target region of C-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol.
Dilution Range: Reconstitute in sterile water for a stock solution.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt.
Endotoxin: <0.1 EU/Mu g of the protein by the LAL method.
Gene Symbol: FSTL3
Gene ID: 10272
Uniprot ID: FSTL3_HUMAN
Immunogen Region: Met27-Val263
Immunogen: Homo sapiens (Human)
Function Isoform 1 or the secreted form is a binding and antagonizing protein for members of the TGF-beta family, such as activin, BMP2 and MSTN. Inhibits activin A-, activin B-, BMP2- and MSDT-induced cellular signaling.more effective on activin A than on activin B. Involved in bone formation.inhibits osteoclast differentiation. Involved in hematopoiesis.involved in differentiation of hemopoietic progenitor cells, increases hematopoietic cell adhesion to fibronectin and seems to contribute to the adhesion of hematopoietic precursor cells to the bone marrow stroma. Isoform 2 or the nuclear form is probably involved in transcriptional regulation via interaction with MLLT10.
Protein Name Follistatin-Related Protein 3
Follistatin-Like Protein 3
Follistatin-Related Gene Protein
Database Links Reactome: R-HSA-2473224
Reactome: R-HSA-381426
Reactome: R-HSA-8957275
Cellular Localisation Isoform 1: Secreted
Isoform 2: Nucleus
Although Alternative Initiation Has Been Demonstrated And Resulted In Different Localization
The Major Source Of Nuclear Fstl3 Appears Not To Depend On Translation Initiation At Met-27 According To
Alternative Protein Names Follistatin-Related Protein 3 protein
Follistatin-Like Protein 3 protein
Follistatin-Related Gene Protein protein
FSTL3 protein
FLRG protein
UNQ674 protein
PRO1308 protein

Information sourced from Uniprot.org

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