Human FRK protein (Recombinant) (N-His) (STJP004719)

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STJP004719
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human FRK-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: FRK
Gene ID: 2444
Uniprot ID: FRK_HUMAN
Immunogen Region: Ile234-Phe491
Immunogen: Homo sapiens (Human)
Function Non-receptor tyrosine-protein kinase that negatively regulates cell proliferation. Positively regulates PTEN protein stability through phosphorylation of PTEN on 'Tyr-336', which in turn prevents its ubiquitination and degradation, possibly by reducing its binding to NEDD4. May function as a tumor suppressor.
Protein Name Tyrosine-Protein Kinase Frk
Fyn-Related Kinase
Nuclear Tyrosine Protein Kinase Rak
Protein-Tyrosine Kinase 5
Database Links Reactome: R-HSA-6798695
Reactome: R-HSA-8948751
Cellular Localisation Cytoplasm
Nucleus
Predominantly Found In The Nucleus
With A Small Fraction Found In The Cell Periphery
Alternative Protein Names Tyrosine-Protein Kinase Frk protein
Fyn-Related Kinase protein
Nuclear Tyrosine Protein Kinase Rak protein
Protein-Tyrosine Kinase 5 protein
FRK protein
PTK5 protein
RAK protein

Information sourced from Uniprot.org

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