• Human Frizzled-5/FZD5 protein (Recombinant) (C-hFc&His) (STJP001134)

Human Frizzled-5/FZD5 protein (Recombinant) (C-hFc&His) (STJP001134)

SKU:
STJP001134

£80.50 - £257.50
Current Stock:
Host: HEK293 cells
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Formulation: Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Determination Method: < 0.1 EU/Mu g of the protein by LAL method.
Gene Symbol: FZD5
Gene ID: 7855
Uniprot ID: FZD5_HUMAN
Immunogen: Recombinant Human Frizzled-5/FZD5 Protein is produced by HEK293 expression system. The target protein is expressed with sequence (Met1-Pro167) of human Frizzled-5 (Accession #NP_003459.2.) fused with an Fc, 6×His tag at the C-terminus.
Immunogen Sequence: MARPDPSAPPSLLLLLLAQL VGRAAAASKAPVCQEITVPM CRGIGYNLTHMPNQFNHDTQ DEAGLEVHQFWPLVEIQCSP DLRFFLCSMYTPICLPDYHK PLPPCRSVCERAKAGCSPLM RQYGFAWPERMSCDRLPVLG RDAEVLCMDYNRSEATTAPP RPFPAKP
Function Receptor for Wnt proteins. Functions in the canonical Wnt/beta-catenin signaling pathway. In vitro activates WNT2, WNT10B, WNT5A, but not WNT2B or WNT4 signaling. In neurons, activation by WNT7A promotes formation of synapses. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues (Probable). Plays a role in yolk sac angiogenesis and in placental vascularization. Plays a role in ocular development.
Protein Name Frizzled-5
Fz-5
Hfz5
Fze5
Database Links Reactome: R-HSA-373080
Reactome: R-HSA-4086398
Reactome: R-HSA-4608870
Reactome: R-HSA-4641262
Reactome: R-HSA-4641263
Reactome: R-HSA-5140745
Reactome: R-HSA-5340588
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Golgi Apparatus Membrane
Synapse
Perikaryon
Cell Projection
Dendrite
Axon
Localized At The Plasma Membrane And Also Found At The Golgi Apparatus
Alternative Protein Names Frizzled-5 protein
Fz-5 protein
Hfz5 protein
Fze5 protein
FZD5 protein
C2orf31 protein

Information sourced from Uniprot.org

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