| Host: | HEK293 cells |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Formulation: | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method: | < 1 EU/Mu g of the protein by LAL method. |
| Gene Symbol: | FZD2 |
| Gene ID: | 2535 |
| Uniprot ID: | FZD2_HUMAN |
| Immunogen: | Recombinant Human Frizzled-2/FZD2 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Gln24-Leu163) of human Frizzled-2/FZD2 (Accession #NP_001457.1) fused with a Fc, 6×His tag at the C-terminus. |
| Immunogen Sequence: | QFHGEKGISIPDHGFCQPIS IPLCTDIAYNQTIMPNLLGH TNQEDAGLEVHQFYPLVKVQ CSPELRFFLCSMYAPVCTVL EQAIPPCRSICERARQGCEA LMNKFGFQWPERLRCEHFPR HGAEQICVGQNHSEDGAPAL |
| Post Translational Modifications | Ubiquitinated by ZNRF3, leading to its degradation by the proteasome. |
| Function | Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. (Microbial infection) Acts as a receptor for C.difficile toxin TcdB in the colonic epithelium. TcdB occupies the binding site for Wnt-adducted palmitoleate in frizzled receptors and TcdB-binding prevents Wnt-binding and downstream Wnt signaling. |
| Protein Name | Frizzled-2 Fz-2 Hfz2 Fze2 |
| Database Links | Reactome: R-HSA-201681 Reactome: R-HSA-373080 Reactome: R-HSA-4086398 Reactome: R-HSA-4608870 Reactome: R-HSA-4641262 Reactome: R-HSA-5140745 |
| Cellular Localisation | Membrane Multi-Pass Membrane Protein Cell Membrane |
| Alternative Protein Names | Frizzled-2 protein Fz-2 protein Hfz2 protein Fze2 protein FZD2 protein |
Information sourced from Uniprot.org
