• Human FR-alpha/FOLR1 protein (Recombinant) (C-His) (STJP001371)

Human FR-alpha/FOLR1 protein (Recombinant) (C-His) (STJP001371)

SKU:
STJP001371

£72.50 - £223.50
Current Stock:
Host: HEK293 cells
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Recombinant-Human FR-alpha/FOLR1-C-His protein was developed from hek293 cells and has a target region of C-His. For use in research applications.
Formulation: Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4.
Gene Symbol: FOLR1
Gene ID: 2348
Uniprot ID: FOLR1_HUMAN
Immunogen: Recombinant Human FR-alpha/FOLR1 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Arg25-Met233) of human FOLR-1/FBP (Accession #NP_000793.1) fused with a 6×His tag at the C-terminus.
Post Translational Modifications The secreted form is derived from the membrane-bound form either by cleavage of the GPI anchor, or/and by proteolysis catalyzed by a metalloprotease.
Function Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release. Required for normal embryonic development and normal cell proliferation.
Protein Name Folate Receptor Alpha
Fr-Alpha
Adult Folate-Binding Protein
Fbp
Folate Receptor 1
Folate Receptor - Adult
Kb Cells Fbp
Ovarian Tumor-Associated Antigen Mov18
Database Links Reactome: R-HSA-204005
Reactome: R-HSA-5694530
Reactome: R-HSA-6807878
Cellular Localisation Cell Membrane
Lipid-Anchor
Gpi-Anchor
Apical Cell Membrane
Basolateral Cell Membrane
Gpi-Like-Anchor
Secreted
Cytoplasmic Vesicle
Clathrin-Coated Vesicle
Endosome
Endocytosed Into Cytoplasmic Vesicles And Then Recycled To The Cell Membrane
Alternative Protein Names Folate Receptor Alpha protein
Fr-Alpha protein
Adult Folate-Binding Protein protein
Fbp protein
Folate Receptor 1 protein
Folate Receptor - Adult protein
Kb Cells Fbp protein
Ovarian Tumor-Associated Antigen Mov18 protein
FOLR1 protein
FOLR protein

Information sourced from Uniprot.org

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