| Host: | Goat/Goat |
| Applications: | ELISA |
| Reactivity: | Human |
| Note: | FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS. |
| Short Description : | This FOLR1 antibody pair contains complimentary capture and detection antibodies, which work together under the principals of the Sandwich ELISA. |
| Conjugation: | Unconjugated/Biotin |
| Formulation: | Capture Buffer: PBS with 0.04% Proclin 300; 50% glycerol; pH 7.5. Detection Buffer: PBS with 0.04% Proclin 300; 1% protective protein; 50% glycerol; pH 7.5. |
| Purification: | Capture Purification: Antigen Affinity. Detection Purification: Antigen Affinity. |
| Concentration: | 0.5 mg/mL |
| Storage Instruction: | Store at-20°C for long term, and avoid freeze-thaw cycles. |
| Determination Method: | Colormetric |
| Gene Symbol: | FOLR1 |
| Gene ID: | 2348 |
| Uniprot ID: | FOLR1_HUMAN |
| Immunogen: | Capture immunogen: Recombinant Human FOLR1 protien. Detection Immunogen: Recombinant Human FOLR1 protien. |
| Sample Type: | Serum, plasma and other biological fluids |
| Post Translational Modifications | The secreted form is derived from the membrane-bound form either by cleavage of the GPI anchor, or/and by proteolysis catalyzed by a metalloprotease. |
| Function | Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release. Required for normal embryonic development and normal cell proliferation. |
| Protein Name | Folate Receptor Alpha Fr-Alpha Adult Folate-Binding Protein Fbp Folate Receptor 1 Folate Receptor - Adult Kb Cells Fbp Ovarian Tumor-Associated Antigen Mov18 |
| Database Links | Reactome: R-HSA-204005 Reactome: R-HSA-5694530 Reactome: R-HSA-6807878 |
| Cellular Localisation | Cell Membrane Lipid-Anchor Gpi-Anchor Apical Cell Membrane Basolateral Cell Membrane Gpi-Like-Anchor Secreted Cytoplasmic Vesicle Clathrin-Coated Vesicle Endosome Endocytosed Into Cytoplasmic Vesicles And Then Recycled To The Cell Membrane |
| Alternative Antibody Pair Names | Folate Receptor Alpha antibody pair Fr-Alpha antibody pair Adult Folate-Binding Protein antibody pair Fbp antibody pair Folate Receptor 1 antibody pair Folate Receptor - Adult antibody pair Kb Cells Fbp antibody pair Ovarian Tumor-Associated Antigen Mov18 antibody pair FOLR1 antibody pair FOLR antibody pair |
Information sourced from Uniprot.org