Human FMO2 protein (Recombinant) (N-His) (STJP006348)

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STJP006348
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human FMO2-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: FMO2
Gene ID: 2327
Uniprot ID: FMO2_HUMAN
Immunogen Region: Gly295-Asn469
Immunogen: Homo sapiens (Human)
Function Catalyzes the oxidative metabolism of numerous xenobiotics, including mainly therapeutic drugs and insecticides that contain a soft nucleophile, most commonly nitrogen and sulfur and participates to their bioactivation. Specifically catalyzes S-oxygenation of sulfur derived compounds such as thioureas-derived compounds, thioetherorganophosphates to their sulfenic acid. In vitro, catalyzes S-oxygenation of the second-line antitubercular drugs thiacetazone (TAZ) and ethionamide (ETA), forming a sulfinic acid and a carbodiimide via a postulated sulfenic acid intermediate. Also catalyzes S-oxygenation of the thioether-containing organophosphate insecticides, phorate and disulfoton.
Protein Name Flavin-Containing Monooxygenase 2
Dimethylaniline Oxidase 2
Fmo 1b1
Pulmonary Flavin-Containing Monooxygenase 2
Fmo 2
Database Links Reactome: R-HSA-217271
Cellular Localisation Microsome Membrane
Single-Pass Membrane Protein
Endoplasmic Reticulum Membrane
Alternative Protein Names Flavin-Containing Monooxygenase 2 protein
Dimethylaniline Oxidase 2 protein
Fmo 1b1 protein
Pulmonary Flavin-Containing Monooxygenase 2 protein
Fmo 2 protein
FMO2 protein

Information sourced from Uniprot.org