Human FLNA protein (Recombinant) (N-His) (STJP004307)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human FLNA-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | FLNA |
| Gene ID | 2316 |
| Uniprot ID | FLNA_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Ser2-Pro274 |
Additional Info
| Post Translational Modifications | Phosphorylation at Ser-2152 is negatively regulated by the autoinhibited conformation of filamin repeats 19-21. Ligand binding induces a conformational switch triggering phosphorylation at Ser-2152 by PKA. Phosphorylation extent changes in response to cell activation. Polyubiquitination in the CH1 domain by a SCF-like complex containing ASB2 leads to proteasomal degradation. Prior dissociation from actin may be required to expose the target lysines. Ubiquitinated in endothelial cells by RNF213 downstream of the non-canonical Wnt signaling pathway, leading to its degradation by the proteasome. |
| Function | Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking. Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance. During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons. |
| Protein Name | Filamin-AFln-AActin-Binding Protein 280Abp-280Alpha-FilaminEndothelial Actin-Binding ProteinFilamin-1Non-Muscle Filamin |
| Database Links | Reactome: R-HSA-114608Reactome: R-HSA-430116Reactome: R-HSA-446353Reactome: R-HSA-5627123Reactome: R-HSA-8983711 |
| Cellular Localisation | CytoplasmCell CortexCytoskeletonPerikaryonCell ProjectionGrowth ConePodosomeColocalizes With Cpmr1 In The Central Region Of Drg Neuron Growth ConeFollowing Sema3a Stimulation Of Drg NeuronsColocalizes With F-ActinLocalized To The Core Of Myotube Podosomes |
| Alternative Protein Names | Filamin-A proteinFln-A proteinActin-Binding Protein 280 proteinAbp-280 proteinAlpha-Filamin proteinEndothelial Actin-Binding Protein proteinFilamin-1 proteinNon-Muscle Filamin proteinFLNA proteinFLN proteinFLN1 protein |
Information sourced from Uniprot.org