Human FLII protein (Recombinant) (N-His) (STJP005280)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human FLII-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | FLII |
| Gene ID | 2314 |
| Uniprot ID | FLII_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Leu896-Phe1176 |
Additional Info
| Function | Is a regulator of actin polymerization, required for proper myofibril organization and regulation of the length of sarcomeric thin filaments. It also plays a role in the assembly of cardiomyocyte cell adhesion complexes. Regulates cytoskeletal rearrangements involved in cytokinesis and cell migration, by inhibiting Rac1-dependent paxillin phosphorylation. May play a role as coactivator in transcriptional activation by hormone-activated nuclear receptors (NR) and acts in cooperation with NCOA2 and CARM1. Involved in estrogen hormone signaling. |
| Protein Name | Protein Flightless-1 Homolog |
| Database Links | |
| Cellular Localisation | NucleusCytoplasmCytoskeletonMicrotubule Organizing CenterCentrosomeCell ProjectionPodosomeCell JunctionFocal AdhesionColocalizes To Actin-Rich Structures In Blastocysts AndTogether With HrasRhoa And Cdc42In Migrating FibroblastsLocalizes To CentrosomesLocalized To The Core Of Macrophage Podosomes |
| Alternative Protein Names | Protein Flightless-1 Homolog proteinFLII proteinFLIL protein |
Information sourced from Uniprot.org