Human FLII protein (Recombinant) (N-His) (STJP005280)

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STJP005280
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human FLII-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: FLII
Gene ID: 2314
Uniprot ID: FLII_HUMAN
Immunogen Region: Leu896-Phe1176
Immunogen: Homo sapiens (Human)
Function Is a regulator of actin polymerization, required for proper myofibril organization and regulation of the length of sarcomeric thin filaments. It also plays a role in the assembly of cardiomyocyte cell adhesion complexes. Regulates cytoskeletal rearrangements involved in cytokinesis and cell migration, by inhibiting Rac1-dependent paxillin phosphorylation. May play a role as coactivator in transcriptional activation by hormone-activated nuclear receptors (NR) and acts in cooperation with NCOA2 and CARM1. Involved in estrogen hormone signaling.
Protein Name Protein Flightless-1 Homolog
Cellular Localisation Nucleus
Cytoplasm
Cytoskeleton
Microtubule Organizing Center
Centrosome
Cell Projection
Podosome
Cell Junction
Focal Adhesion
Colocalizes To Actin-Rich Structures In Blastocysts And
Together With Hras
Rhoa And Cdc42
In Migrating Fibroblasts
Localizes To Centrosomes
Localized To The Core Of Macrophage Podosomes
Alternative Protein Names Protein Flightless-1 Homolog protein
FLII protein
FLIL protein

Information sourced from Uniprot.org

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