Human FLG2 protein (Recombinant) (N-His) (STJP005545)

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STJP005545
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human FLG2-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: FLG2
Gene ID: 388698
Uniprot ID: FILA2_HUMAN
Immunogen Region: Glu1222-Gln1368
Immunogen: Homo sapiens (Human)
Post Translational Modifications Deiminated by PADI1, PADI2 or PADI3 in vitro. The deiminated form is degraded by calpain-1/CAPN1 more quickly and into shorter peptides than the intact protein. May be processed by calpain-1/CAPN1 in the uppermost epidermal layers.
Function Essential for normal cell-cell adhesion in the cornified cell layers. Important for proper integrity and mechanical strength of the stratum corneum of the epidermis.
Protein Name Filaggrin-2
Flg-2
Intermediate Filament-Associated And Psoriasis-Susceptibility Protein
Ifapsoriasin
Database Links Reactome: R-HSA-6798695
Cellular Localisation Cytoplasm
Cytoplasmic Granule
In The Stratum Corneum Of The Epidermis
Dispersed Diffusely Throughout The Cytoplasm
While In The Stratum Granulosum
Localized Within Keratohyalin Granules
In Granular Keratinocytes And In Lower Corneocytes
Colocalizes With Calpain-1/Capn1
Alternative Protein Names Filaggrin-2 protein
Flg-2 protein
Intermediate Filament-Associated And Psoriasis-Susceptibility Protein protein
Ifapsoriasin protein
FLG2 protein
IFPS protein

Information sourced from Uniprot.org

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