Post Translational Modifications | Deiminated by PADI1, PADI2 or PADI3 in vitro. The deiminated form is degraded by calpain-1/CAPN1 more quickly and into shorter peptides than the intact protein. May be processed by calpain-1/CAPN1 in the uppermost epidermal layers. |
Function | Essential for normal cell-cell adhesion in the cornified cell layers. Important for proper integrity and mechanical strength of the stratum corneum of the epidermis. |
Protein Name | Filaggrin-2Flg-2Intermediate Filament-Associated And Psoriasis-Susceptibility ProteinIfapsoriasin |
Database Links | Reactome: R-HSA-6798695 |
Cellular Localisation | CytoplasmCytoplasmic GranuleIn The Stratum Corneum Of The EpidermisDispersed Diffusely Throughout The CytoplasmWhile In The Stratum GranulosumLocalized Within Keratohyalin GranulesIn Granular Keratinocytes And In Lower CorneocytesColocalizes With Calpain-1/Capn1 |
Alternative Protein Names | Filaggrin-2 proteinFlg-2 proteinIntermediate Filament-Associated And Psoriasis-Susceptibility Protein proteinIfapsoriasin proteinFLG2 proteinIFPS protein |
Information sourced from Uniprot.org