Human FKBP8 protein (Recombinant) (N-His) (STJP015478)

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STJP015478
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Host: E.coli
Applications: ELISA/Immunogen/SDS-PAGE/WB
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human FKBP8-N-His protein was developed from e.coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol.
Dilution Range: Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Endotoxin: Please contact us for further information.
Gene Symbol: FKBP8
Gene ID: 23770
Uniprot ID: FKBP8_HUMAN
Immunogen Region: Gly100-Leu368
Immunogen: Homo sapiens (Human)
Post Translational Modifications Ubiquitinated by PRKN during mitophagy, leading to its degradation and enhancement of mitophagy. Deubiquitinated by USP30.
Function Constitutively inactive PPiase, which becomes active when bound to calmodulin and calcium. Seems to act as a chaperone for BCL2, targets it to the mitochondria and modulates its phosphorylation state. The BCL2/FKBP8/calmodulin/calcium complex probably interferes with the binding of BCL2 to its targets. The active form of FKBP8 may therefore play a role in the regulation of apoptosis. Involved in the inhibition of viral infection by influenza A viruses (IAV).
Protein Name Peptidyl-Prolyl Cis-Trans Isomerase Fkbp8
Ppiase Fkbp8
38 Kda Fk506-Binding Protein
38 Kda Fkbp
Fkbp-38
Hfkbp38
Fk506-Binding Protein 8
Fkbp-8
Fkbpr38
Rotamase
Database Links Reactome: R-HSA-5689880
Cellular Localisation Mitochondrion
Mitochondrion Membrane
Single-Pass Membrane Protein
Cytoplasmic Side
Isoform 1: Mitochondrion Membrane
Isoform 3: Mitochondrion Membrane
Alternative Protein Names Peptidyl-Prolyl Cis-Trans Isomerase Fkbp8 protein
Ppiase Fkbp8 protein
38 Kda Fk506-Binding Protein protein
38 Kda Fkbp protein
Fkbp-38 protein
Hfkbp38 protein
Fk506-Binding Protein 8 protein
Fkbp-8 protein
Fkbpr38 protein
Rotamase protein
FKBP8 protein
FKBP38 protein

Information sourced from Uniprot.org

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